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In the ensuing years, it has been attached to a variety of constructsincluding exendin-4, RGD, and an anti-tissue factor Fabto increase their blood half-lives, but it has attracted particular attention in radiopharmaceutical chemistry

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Although glutathionylation of the lipoyl moiety prevents oxidative damage to the E1 component, it also maintains a reduced flavin on the E3 subunit, and this may contribute to oxidative damage by E3-mediated ROS production (58)